HYPOLIPIDAEMIC EFFECT OF COLD AQUEOUS EXTRACT MIXTURES OF GRAPE (VITIS VINIVERA ) SEED, BASIL (OCIMUM BASILICUM) LEAVES AND MORINGA (MORINGA OLEIFERA) LEAVES IN RATS

Document Type : original papers

Authors

Food Science and technology Department, of Agriculture, Minufiya University, Shebien EL-kom, Egypt.

Abstract

Different mixtures of (Moringa olifera leaves. Ocimum basilcum leaves and Grape seeds) as Mix A (Moringa leaves. basil leaves and Grape seeds), Mix. B (Moringa leaves and basil leaves), Mix. C Moringa olifera leaves and Grape seeds) and Mix D (basil leaves and Grape seeds) were analyzed for its total phenolic, total flavonoids contents, phenolic and flavonoids compounds then oral administration different mixtures with (200 and 100bwmg/k) to 60 sixty albino hypercholesterolemic rats aiming to improve their lipid profile. By the end of the experiment (28days) TC, TG, LDL, HDL, atherogenic indices (AC, CRR, AI) were analyzed.  Mix A contained Total phenolic and Total flavonoid 1.23 and 0.07, Mix B 1.06 and 0.07, Mix C 1.46 and 0.09, Mix D 1.16 and 0.06 respectively.  The highest total phenolic content and flavonoid in Mix C (1.46mg GAE g−1 DW) and flavonoid content (0.0068 mg QE). Narinigin the major compound flavonoid of Mix A. Mix B and Mix C as 2165.36 ppm, 9201.27ppm and2978.04 ppm. While Hesperidin910.17ppm major compound flavonoid of Mix D. The total cholesterol, triglyceride and LDL ratios were improved by 14.98%, 36.93% and 25.09% in groups were treated with Mix A (200mg/kbw) compared with the positive control group. Significant high density lipoprotein (HDL) cholesterol and atherogenic indices (AC, CRR, AI), implying that hypochol-esterolemic effects of Mix. A 200mg/bw of rats were partly attributed to the reduced absorption of lipid and cholesterol.

Keywords

Menoufia Journal of Food and Dairy Sciences
Volume 4, Issue 5 - Serial Number 5
November and December 2019
Pages 153-169

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